A high-level training activity took place during the 48ª Congress of the Spanish Association for the Study of the Liver: a Masterclass focused on the Prevention of liver diseases, highlighting the importance of Public Health policies. This activity, led by Profs José Luis Calleja (Gastroenterology and Hepatology Service; Puerta de Hierro University Hospital, Spain) and Javier Crespo (Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Santander, Spain), was attended by the Prof. Manal El-Sayed (Professor of Pediatric Medicine, Chair of the Pediatric Department and founder and Director of the Clinical Research Center, Faculty of Medicine, Ain Shams University (MASRI-CRC), Cairo, Egypt), the Prof. Shira Zelber-Sagi (Head and professor at the School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Israel. Department Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv) and Prof. Ramón Bataller (Chair of the Liver Unit, Hospital Clinic in Barcelona). In addition, the debate was joined by Prof. María Buti (Digestive Service, Vall d’Hebron University Hospital, Barcelona) and Prof. Jeffrey V. Lazarus (Health Systems Research Group, Barcelona Institute For Global Health, ISGlobal). A discussion forum where the change from the «old» Hepatology to the new hepatology was glimpsed, which could well be summed up with these phrases «tweeted» by Dr. Ramón Bataller: Old Hepatology focused on advanced cases and current Hepatology focuses on early detection. Future Hepatology should focus on Prevention. From reactive to predictive, preventive and personalized hepatology.